Journal: Pharmaceutics

Article Title: Analysis of the Dissolution Mechanism of Drugs into Polymers: The Case of the PVP/Sulindac System

doi: 10.3390/pharmaceutics15051505

Figure Lengend Snippet: Total, reversible and non-reversible heat flow curves recorded during the heating MDSC scan of a MCD (Molecular and Crystalline Dispersion) of sulindac/PVP [85:15] w . The scan was performed at 5 °C/min using a modulation amplitude of 0.663 °C and a modulation period of 50 s. ( a – c ) and ** mark the main thermal events discussed in the text. The inset illustrates the schematic trajectory of the sample in the state diagram of the sulindac/PVP mixture during the heating process.

Article Snippet: The milling times (t m ) ranged between 0 min (non-milled material) and 50 h. Differential Scanning Calorimetry (DSC) and temperature Modulated DSC (MDSC) experiments were performed with the DSC Discovery of TA Instruments.

Techniques: Dispersion

Journal: Pharmaceutics

Article Title: Analysis of the Dissolution Mechanism of Drugs into Polymers: The Case of the PVP/Sulindac System

doi: 10.3390/pharmaceutics15051505

Figure Lengend Snippet: Total, reversible and non-reversible heat flow curves recorded during the heating MDSC scan of a physical mixture sulindac/PVP [20:80] w . The scan was performed at 5 °C/min using a modulation amplitude of 0.663 °C and a modulation period of 50 s. ( a , b ) mark the main thermal events discussed in the text. The inset illustrates the schematic trajectory of the sample in the state diagram of the sulindac/PVP mixture during the heating process.

Article Snippet: The milling times (t m ) ranged between 0 min (non-milled material) and 50 h. Differential Scanning Calorimetry (DSC) and temperature Modulated DSC (MDSC) experiments were performed with the DSC Discovery of TA Instruments.

Techniques:

Journal: Pharmaceutics

Article Title: Analysis of the Dissolution Mechanism of Drugs into Polymers: The Case of the PVP/Sulindac System

doi: 10.3390/pharmaceutics15051505

Figure Lengend Snippet: Total, reversible and non-reversible heat flow curves recorded during the heating MDSC scan of a homogeneous glass solution sulindac/PVP [85:15] w . The scan was performed at 5 °C/min using a modulation amplitude of 0.663 °C and a modulation period of 50 s. ( a – c ), * and ** mark the main thermal events discussed in the text. The inset illustrates the schematic trajectory of the sample in the state diagram of the sulindac/PVP mixture during the heating process.

Article Snippet: The milling times (t m ) ranged between 0 min (non-milled material) and 50 h. Differential Scanning Calorimetry (DSC) and temperature Modulated DSC (MDSC) experiments were performed with the DSC Discovery of TA Instruments.

Techniques:

Journal: Pharmaceutics

Article Title: Development of Remdesivir as a Dry Powder for Inhalation by Thin Film Freezing

doi: 10.3390/pharmaceutics12111002

Figure Lengend Snippet: Modulated differential scanning calorimetry (mDSC) thermograms; ( A ) remdesivir unprocessed powder; ( B ) TFF remdesivir powder formulations.

Article Snippet: Modulated differential scanning calorimetry (mDSC) was employed to identify the glass-forming ability of remdesivir and determine the glass transition temperature (Tg) of remdesivir in each formulation.

Techniques:

Journal: Pharmaceutics

Article Title: Co-Amorphous Solid Dispersion System for Improvement in Dissolution Profile of N -(((1 r ,4 r )-4-((6-fluorobenzo[ d ]oxazol-2-yl)amino)cyclohexyl)methyl)-2-methylpropane-2-sulfonamide as a Neuropeptide Y5 Receptor Antagonist

doi: 10.3390/pharmaceutics16101293

Figure Lengend Snippet: mDSC profiles: ( a ) ST and polymers, ball-milled (BM) ( b ) ST–polymer and ( c ) NP-ST/NP-ST–polymer. The solid and dashed lines represent reversing and non-reversing heat flows, respectively.

Article Snippet: Modulated differential scanning calorimetry (mDSC) was performed to determine the Tg and crystallization point ( Tc ) using a Discovery DSC (TA Instruments Japan, Shinagawa, Tokyo, Japan).

Techniques: Polymer